Results showed a significant reduction in transfusion burden compared to placebo
Safety profile generally consistent with previously reported data
Regulatory submissions planned in the United States and Europe in the first half of 2019
SUMMIT, N.J. & CAMBRIDGE, Mass-Tuesday 10 July 2018 [ AETOS Wire ]
(BUSINESS WIRE)-- Celgene Corporation (NASDAQ: CELG) and Acceleron Pharma Inc. (NASDAQ: XLRN) today announced results from a phase III, randomized, double-blind, multi-center clinical study (BELIEVE). Luspatercept achieved a highly statistically significant improvement in the primary endpoint of erythroid response, which was defined as at least a 33 percent reduction from baseline in red blood cell (RBC) transfusion burden with a reduction of at least 2 units during the protocol-defined period of 12 consecutive weeks, from week 13 to week 24, compared to placebo.
BELIEVE evaluated the efficacy and safety of luspatercept plus be
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